Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

This update, written by authors designated by multiple pediatric endocrinology societies
(see List of Participating Societies) from around the globe, concisely addresses topics …

OBJECTIVE. Gonadotropin-releasing hormone analogs revolutionized the treatment of
central precocious puberty. However, questions remain regarding their optimal use in …

Central precocious puberty (CPP) results from early activation of the hypothalamic-pituitary-
gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors …

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain
challenging due to lack of standardization. The aim of this revision was to address the …

Central precocious puberty (CPP) is characterized by the same biochemical and physical
features as normally timed puberty but occurs at an abnormally early age. Most cases of …

GnRH analogues (GnRHa) are the treatment of choice for central precocious puberty (CPP),
with the main objective to recover the height potential compromised by the premature fusion …

Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central
precocious puberty (CPP) worldwide and have an enviable track record of safety and …

Objective: The objective of the study was to evaluate the long-term effect of GnRH analog
(GnRHa) treatment on final height (FH), body mass index (BMI), body composition, bone …