Synthetic and Natural Bioactive Molecules in Balancing the Crosstalk among Common Signaling Pathways in Alzheimer's Disease: Understanding the Neurotoxic …

AJ Shah, PA Mir, M Adnan, M Patel, M Maqbool… - ACS …, 2023 - ACS Publications
The structure and function of the brain greatly rely on different signaling pathways. The wide
variety of biological processes, including neurogenesis, axonal remodeling, the …

Small molecule natural products and Alzheimer's disease

X Wu, H Cai, L Pan, G Cui, F Qin… - Current topics in …, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive and deadly neurodegenerative disease that is
characterized by memory loss, cognitive impairment and dementia. Several hypotheses …

Thermodynamic sensitivity of blood plasma components in patients afflicted with skin, breast and pancreatic forms of cancer

A Ferencz, D Szatmári, D Lőrinczy - Cancers, 2022 - mdpi.com
Simple Summary Based on the World Health Organization's global survey, conducted over
the past five years, cancer is the second leading cause of death. According to its database …

Natural product formulations for the prevention and treatment of Alzheimer's disease: a patent review

R Koynova, B Tenchov - Recent patents on drug delivery & …, 2018 - ingentaconnect.com
Introduction: Although considerable efforts have been made to develop effective therapeutic
agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of …

Exploratory analysis of iPSCS-derived neuronal cells as predictors of diagnosis and treatment of Alzheimer disease

E Cavalli, G Battaglia, MS Basile, V Bruno, MC Petralia… - Brain sciences, 2020 - mdpi.com
Alzheimer's disease (AD) represents the most common neurodegenerative disorder, with 47
million affected people worldwide. Current treatment strategies are aimed at reducing the …

Beneficial effect of sequential chemotherapy treatments of lung cancer patients revealed by calorimetric monitoring of blood plasma proteome denaturation

R Koynova, B Antonova, B Sezanova, B Tenchov - Thermochimica Acta, 2018 - Elsevier
Blood plasma heat capacity profiles of lung cancer patients were recorded by DSC and
monitored during a first-line chemotherapy cycle including four sessions of treatment by a …

Blood plasma thermal behavior and protein oxidation as indicators of multiple sclerosis clinical status and plasma exchange therapy progression

B Tenchov, R Koynova, B Antonova, S Zaharinova… - Thermochimica …, 2019 - Elsevier
Multiple sclerosis (MS), a leading cause of physical disability in young adults, is a chronic
autoimmune neuroinflammatory disease characterized by axonal injury and demyelination …

Type IV collagen conforms to the organization of polylaminin adsorbed on planar substrata

T Coelho-Sampaio, B Tenchov, MA Nascimento… - Acta Biomaterialia, 2020 - Elsevier
Tissue engineering demands the development of scaffolds that mimic natural extracellular
matrices (ECM). Despite the success in obtaining synthetic interstitial ECM, the production of …

Controllable enzymatic superactivity of α-chymotrypsin activated by the electrostatic interaction with cationic gemini surfactants

Z Yue, M Yao, G Bai, J Wang, K Zhuo, J Wang… - RSC advances, 2021 - pubs.rsc.org
Surfactant plays a critical role in enzymatic multi-functionalization processes. However, a
deep understanding of surfactant-enzyme interactions has been lacking up until now due to …

Exothermic transitions in the heat capacity profiles of human cerebrospinal fluid

B Antonova, E Naydenov, R Koynova… - European Biophysics …, 2020 - Springer
In this work, we examined by DSC protein denaturation heat capacity profiles for two body
fluids, cerebrospinal fluid (CSF) and blood plasma obtained from brain tumor (mainly …