▪ Abstract Small ubiquitin-related modifier (SUMO) family proteins function by becoming
covalently attached to other proteins as post-translational modifications. SUMO modifies …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Histone deacetylases (HDACs) modify core histones and participate in large regulatory
complexes that both suppress and enhance transcription. Recent studies indicate that some …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular
diseases and in particular with atherosclerosis and plaque instability. However, the …

▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …

The base sequence of DNA provides the genetic code for proteins. The regulation of
expression or suppression of gene transcription is largely determined by the structure of the …

Three fundamental issues in postgenomic biology are (i) how the amino acid sequence of a
given human protein predicates its structure, function, and regulation;(ii) how a protein is …

Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Purpose: Our objective was to identify the genetic changes involved in primary central
nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance …