Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response
in the host may cause the destruction of supporting periodontal tissue. Macrophages play a …

Periodontitis is the sixth-most prevalent disease in the world and the first cause for tooth loss
in adults. With focus shifted to the inflammatory/immune response in the pathogenesis of …

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that
byproducts from joint replacements induce an inflammatory reaction that can result in …

Long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered
essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts …

Single trauma injuries or isolated fractures are often manageable and generally heal without
complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns …

The aim of this review was to update the evidence of new approaches to non-surgical
therapy (NSPT) in the treatment of periodontitis. Preclinical and clinical studies addressing …

Maresin-1 (MaR1) and Resolvin E1 (RvE1) are specialized pro-resolving lipid mediators
(SPMs) that regulate inflammatory processes. We have previously demonstrated the hard …

Bone metabolism is a lifelong process that includes bone formation and resorption.
Osteoblasts and osteoclasts are the predominant cell types associated with bone …

Systemic, chronic, low-grade inflammation (SCLGI) underlies the pathogenesis of various
widespread diseases. It is often associated with bone loss, thus connecting chronic …

Periodontitis is known to be initiated by periodontal microbiota derived from biofilm
formation. The microbial dysbiotic changes in the biofilm trigger the host immune and …