Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

Epicardial epithelial-to-mesenchymal transition (EMT) plays a pivotal role in both heart
development and injury response and involves dynamic cellular changes that are essential …

The regenerative capacity of the mammalian heart is poor, with one potential reason being
that adult cardiomyocytes cannot proliferate at sufficient levels to replace lost tissue. During …

Macrophages conduct critical roles in heart repair, but the niche required to nurture and
anchor them is poorly studied. Here, we investigated the macrophage niche in the …

The epicardium, previously viewed as a passive outer layer around the heart, is now
recognized as an essential component in development, regeneration, and repair. In this …

Balancing between regenerative processes and fibrosis is crucial for heart repair, yet
strategies regulating this balance remain a barrier to developing therapies. The role of …

After traumatic injury, healing of mammalian ligaments is typically associated with fibrotic
scarring as opposed to scar-free regeneration. In contrast, here we show that the ligament …

Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality.
Early revascularisation in acute myocardial infarction has improved survival; however …

The development of atherosclerotic cardiovascular disease is associated with the
phenotypic switching of vascular smooth muscle cells (SMCs) from a contractile to a …

One of the enduring debates in regeneration biology is the degree to which regeneration
mirrors development. Recent technical advances, such as single-cell transcriptomics and …