In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

Increasing evidence points to a complex interplay between genes and the environment in
autism spectrum disorder (ASD), including rare de novo mutations in chromatin genes such …

Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …

Traumatic stress is a type of environmental experience that can modify behavior, cognition
and physiological functions such as metabolism, in mammals. Many of the effects of …

Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …

The ability of the environment to shape cortical function is at its highest during critical
periods of postnatal development. In the visual cortex, critical period onset is triggered by the …

Hemispheric asymmetries represent one of the major organizational principles in vertebrate
neurobiology, but their molecular determinants are not well understood. For handedness …

Brain plasticity refers to the ability of synaptic connections to adapt their function and
structure in response to experience, including environmental changes, sensory deprivation …

Experience-dependent plasticity is the ability of brain circuits to undergo molecular,
structural and functional changes as a function of neural activity. Neural activity continuously …