Technological advances and breakthrough developments in the pharmaceutical field are
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …

Thioamides, which are fascinating isosteres of amides, have garnered significant attention in
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …

Cyclic peptides are versatile therapeutic agents that boast high binding affinity, minimal
toxicity, and the potential to engage challenging protein targets. However, the …

Ion channels serve pleiotropic functions. Often found in complexes, their activities and
functions are sculpted by auxiliary proteins. We discovered that collapsin response mediator …

Macrocyclic peptides have garnered significant attention as promising drug candidates.
However, they typically face challenges in achieving and enhancing cell permeability for …

The cell-penetrating peptide (CPP) penetratin has gained much attention over many years
due to its potential role as a transporter for a broad range of cargo into cells. The …

In this study, we present the synthesis of five novel compounds by combining flurbiprofen
with various substituted 2-phenethylamines. The synthesized derivatives underwent …

Since last century, peptides have emerged as potential drugs with> 90 FDA approvals for
various targets with several in the pipeline. Sulphur, in peptides is present either as thiol …

Proteins are synthesized within ribosomes through the polymerization of amino acids (AAs).
This process requires prior activation of AAs through aminoacylation that attaches them to …

Thioamides have structural and chemical similarity to peptide bonds, offering valuable
insights when probing peptide backbone interactions, but are prone to side reactions during …