The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with
infected or transformed target cells and then secreting cytotoxic perforin and granzyme into …

Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell
biology has attracted considerable attention in the immunology community. Long-term …

TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …

T follicular helper (Tfh) cells provide signals to initiate and maintain the germinal center (GC)
reaction and are crucial for the generation of robust, long-lived antibody responses, but how …

The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the
migration, adhesion, and activation of T cells through interactions with intercellular adhesion …

Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most
complex and difficult viral infections to cure. The difficulty in developing curative strategies …

ABSTRACT T cell entry into inflamed tissue requires firm adhesion, cell spreading, and
migration along and through the endothelial wall. These events require the T cell integrins …

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 allows for precise
gene targeting in mammalian cells, including T cells, allowing scientists to disrupt or edit …

IL-10 is a pleiotropic cytokine that plays a significant role in antiviral and antitumor immunity.
Potent CD8+ T cells express IL-10 after stimulation by strong TCR signaling, which promotes …