Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well
as being a substrate for a number of NAD-consuming enzymes (eg, PARPS, sirtuins, etc) …

Highlights•NAMPT is overexpressed in cancers, associating with a poor prognosis and
tumor progression.•Extensive efforts have been made to improve efficacy and safety of early …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem …

Abstract Selinexor (KPT-330), a small-molecule inhibitor of exportin-1 (XPO1, CRM1) with
potent anticancer activity, has recently been granted FDA approval for treatment of …

NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in
oxidation–reduction (redox) reactions in various energy production processes, such as the …

Arrayed CRISPR libraries extend the scope of gene-perturbation screens to non-selectable
cell phenotypes. However, library generation requires assembling thousands of vectors …

Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat
with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral …

A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating
levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare …

Genome-wide CRISPR phenotypic screens are clarifying many fundamental biological
phenomena. While pooled screens can be used to study selectable features, arrayed …