The resistance of pathogenic fungi and failure of drug therapy increased dramatically.
Numerous studies have reported the individual or synergistic antifungal potency of natural …

Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug
discovery. Also, chroman-4-ones are important intermediates and interesting building blocks …

Flavonoids, possessing a basic phenylbenzopyrone core, are important components of the
human diet, and are found in many medicinal plants. Flavonoids include chalcones …

Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin
derivatives, triazole-tethered monocarbonyl curcumin–coumarin and curcumin–isatin …

In the present study novel heterocyclic tetrads containing furan, pyrazoline, thiazole and
triazole (or oxadiazole)(1, 2, 3, 4a-e and 5a-e) were designed and synthesized and …

Epilepsy is one of the most important neurological disorders with high prevalence
worldwide. Many epileptic patients are not completely treated with available drugs and need …

Currently, the available antifungal agents have significant clinical incompetency in terms of
their clinical efficacy, antifungal spectrum, unfavorable pharmacokinetic profiles, substantial …

Leishmaniasis is a group of protozoan parasitic diseases caused by various Leishmania
species. The clinical manifestations range from skin abrasions to lethal infection in the …

Abstract Copper (I) iodide (CuI) was grafted on oxa-and aza-ligand-functionalized
polyacrylonitrile fibers (PANFs) to obtain highly active catalysts for the 1, 3-dipolar …

Objectives Pentavalent antimonials have been used for the treatment of leishmaniasis for
over 70 years, however they are limited by their toxicity. Unfortunately, the efficacy of first …