Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

There is a long-held consensus that several proteins are unique to small extracellular
vesicles (EVs), such as exosomes. However, recent studies have shown that several of …

Kynurenic acid (KynA) is tissue protective in cardiac, cerebral, renal, and retinal ischemia
models, but the mechanism is unknown. KynA can bind to multiple receptors, including the …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …

Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER)
is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport …

The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …