The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
Central role of oxidative stress in age‐related macular degeneration: evidence from a review of the molecular mechanisms and animal models
Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …
elderly. There are very limited therapeutic options for AMD with the predominant therapies …
Complement factor H in AMD: Bridging genetic associations and pathobiology
CB Toomey, LV Johnson, CB Rickman - Progress in retinal and eye …, 2018 - Elsevier
Abstract Age-Related Macular Degeneration (AMD) is a complex multifactorial disease
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …
[HTML][HTML] Implications of genetic variation in the complement system in age-related macular degeneration
Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …
in the Western world. While AMD is a multifactorial disease, the complement system was …
Regulation of age-related macular degeneration-like pathology by complement factor H
CB Toomey, U Kelly, DR Saban… - Proceedings of the …, 2015 - National Acad Sciences
Complement factor H (CFH) is a major susceptibility gene for age-related macular
degeneration (AMD); however, its impact on AMD pathobiology is unresolved. Here, the role …
degeneration (AMD); however, its impact on AMD pathobiology is unresolved. Here, the role …
Retinal pigment epithelium in the pathogenesis of age‐related macular degeneration and photobiomodulation as a potential therapy?
The retinal pigment epithelium (RPE) comprises a monolayer of cells located between the
neuroretina and the choriocapillaries. The RPE serves several important functions in the …
neuroretina and the choriocapillaries. The RPE serves several important functions in the …
Complement in removal of the dead–balancing inflammation
M Martin, AM Blom - Immunological reviews, 2016 - Wiley Online Library
Recognition and removal of apoptotic and necrotic cells must be efficient and highly
controlled to avoid excessive inflammation and autoimmune responses to self. The …
controlled to avoid excessive inflammation and autoimmune responses to self. The …
Discs of mammalian rod photoreceptors form through the membrane evagination mechanism
Photoreceptor discs are membrane organelles harboring components of the visual signal
transduction pathway. The mechanism by which discs form remains enigmatic and is the …
transduction pathway. The mechanism by which discs form remains enigmatic and is the …
AMD and the alternative complement pathway: genetics and functional implications
PL Tan, C Bowes Rickman, N Katsanis - Human genomics, 2016 - Springer
Age-related macular degeneration (AMD) is an ocular neurodegenerative disorder and is
the leading cause of legal blindness in Western societies, with a prevalence of up to 8 …
the leading cause of legal blindness in Western societies, with a prevalence of up to 8 …
Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice
M Landowski, U Kelly, M Klingeborn… - Proceedings of the …, 2019 - National Acad Sciences
One of the strongest susceptibility genes for age-related macular degeneration (AMD) is
complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved …
complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved …