Background Metabolomics is a well-established rapidly developing research field involving
quantitative and qualitative metabolite assessment within biological systems. Recent …

Secondary metabolites are bioactive substances with diverse chemical structures.
Depending on the ecological environment within which they are living, higher plants use …

A critical challenge for environmental chemical risk assessment is the characterization and
reduction of uncertainties introduced when extrapolating inferences from one species to …

Motivation: Although metabolic reactions are unquestionably shaped by evolutionary
processes, the degree to which the overall structure and complexity of their interconnections …

Motivation: Given a pair of metabolic pathways, an alignment of the pathways corresponds
to a mapping between similar substructures of the pair. Successful alignments may provide …

Background Pathways provide topical descriptions of cellular circuitry. Comparing
analogous pathways reveals intricate insights into individual functional differences among …

Background Comparative analysis of metabolic networks in multiple species yields
important information on their evolution, and has great practical value in metabolic …

" Inferring evolutionary relationships among a collection of organisms--that is, their
relationship to each other on the tree of life--remains a central focus of much of evolutionary …

Background MetaDAG is a web-based tool developed to address challenges posed by big
data from omics technologies, particularly in metabolic network reconstruction and analysis …

Using a metabolic pathway alignment method we developed, we studied highly conserved
reactions in different groups of organisms and found out that biological functions vital for …