CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

As per the WHO, colorectal cancer (CRC) caused around 935,173 deaths worldwide in 2020
in both sexes and at all ages. The available anticancer therapies including chemotherapy …

Biofabrication, including printing technologies, has emerged as a powerful approach to the
design of disease models, such as in cancer research. In breast cancer, adipose tissue has …

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water
volume loss and viscoelasticity or injected into the knee to restore the properties of synovial …

Soft tissue defects are a common clinical challenge mostly caused by trauma, congenital
anomalies and oncological surgery. Current soft tissue reconstruction options include …

Medical adhesives are advanced but challenging alternatives to wound closure and repair,
especially in mitigating uncontrolled hemorrhage. Ideal hemostatic adhesives need to meet …

Background Bacterial infection, complex wound microenvironment and persistent
inflammation cause delayed wound healing and scar formation, thereby disrupting the …

The globally increasing prevalence of obesity is associated with the development of
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …

Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA
synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat the disease …