Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Various pre-clinical models with different specific features of the disease …

Oligodendrocytes (OLGs) are generated late in development and myelination is thus a
tardive event in the brain developmental process. It is however maintained whole life long at …

Injury of oligodendrocytes (OLs) induces demyelination, and patients with
neurodegenerative diseases exhibit demyelination concomitantly with neurological deficit …

Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a
copper chelator, is widely used to study demyelination and remyelination in the CNS, in the …

Progressive phases of multiple sclerosis are associated with inhibited differentiation of the
progenitor cell population that generates the mature oligodendrocytes required for …

There is a need for accurate quantitative non-invasive biomarkers to monitor myelin
pathology in vivo and distinguish myelin changes from other pathological features including …

Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination
failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in …

Although MRI is the gold standard for the diagnosis and monitoring of multiple sclerosis
(MS), current conventional MRI techniques often fail to detect cortical alterations and provide …

Remyelination is a major therapeutic goal in human myelin disorders, serving to restore
function to demyelinated axons and providing neuroprotection. The target disorders that …

Over the past several decades, significant advances have been made in identifying factors
that contribute to the pathogenesis of multiple sclerosis (MS) and have culminated in the …