Proton pump inhibitors (PPIs), such as omeprazole, lansoprazole, rabeprazole,
esomeprazole, and pantoprazole, are mainly metabolized by CYP2C19 in the liver. There …

Tigecycline is the first commercially available member of the glycylcyclines, a new class of
antimicrobial agents. The glycylcyclines are derivatives of the tetracycline antibiotics, with …

Biofilms are associated with a wide variety of bacterial infections and pose a serious
problem in clinical medicine due to their inherent resilience to antibiotic treatment. Within …

A series of pleuromutilin derivatives with 1, 2, 4-triazole-3-substituted Schiff base structure
were designed and synthesized under mild conditions. The in vitro antibacterial activities of …

The cure rates of Helicobacter pylori (H. pylori) eradication therapy using a proton pump
inhibitor (PPI) and antimicrobial agents such as amoxicillin, clarithromycin, and …

Acinetobacter baumannii is Gram-negative, an opportunistic pathogen responsible for life-
threatening ventilator-associated pneumonia. World Health Organization (WHO) enlisted it …

Abstract Backgrounds and Aims Development of safe and effective rescue regimens for
eradication failure of Helicobacter pylori infection by standard regimens is an urgent task …

Efflux pumps are one of the major determinants of multiple drug resistance. In this study,
AbeM, a multidrug efflux pump in Acinetobacter baumannii, was cloned into a multicopy …

Background Insufficient acid inhibition during Helicobacter pylori eradication treatment and
bacterial resistance to antibiotics often causes eradication failure. Four times daily dosing …

Background Rifabutin has been known to be effective in multidrug‐resistant Helicobacter
pylori‐harboring patients undergoing treatment failure for H. pylori infection. Aim To evaluate …