Optimizing pharmacokinetics of intravesical chemotherapy for bladder cancer

GA Joice, TJ Bivalacqua, M Kates - Nature Reviews Urology, 2019 - nature.com
Non-muscle-invasive bladder cancer (NMIBC) remains one of the most common
malignancies and is associated with considerable treatment costs. Patients with …

Current clinical trials in non-muscle-invasive bladder cancer: heightened need in an era of chronic BCG shortage

VT Packiam, RP Werntz, GD Steinberg - Current urology reports, 2019 - Springer
Purpose of Review BCG is the gold standard agent used in high-risk non-muscle-invasive
bladder cancer (NMIBC) that is amenable to bladder sparing management. However, recent …

Expression level of urinary microRNA-146a-5p is increased in patients with bladder cancer and decreased in those after transurethral resection

H Sasaki, M Yoshiike, S Nozawa, W Usuba… - Clinical genitourinary …, 2016 - Elsevier
Background Bladder cancer is the most prevalent malignancy involving the urinary system
and exhibits a markedly high recurrence rate. Therefore, reliable and noninvasive diagnostic …

Non–muscle‐invasive bladder cancer: Intravesical treatments beyond Bacille C almette‐G uérin

VT Packiam, SC Johnson, GD Steinberg - Cancer, 2017 - Wiley Online Library
An unmet need exists for patients with high‐risk non–muscle‐invasive bladder cancer for
whom bacille Calmette‐Guérin (BCG) has failed and who seek further bladder‐sparing …

Nanodiamonds as possible tools for improved management of bladder cancer and bacterial cystitis

D Zupančič, P Veranič - International Journal of Molecular Sciences, 2022 - mdpi.com
Nanodiamonds (NDs) are a class of carbon nanomaterials with sizes ranging from a few nm
to micrometres. Due to their excellent physical, chemical and optical properties, they have …

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer

MG Netea, LAB Joosten… - Journal of leukocyte …, 2017 - academic.oup.com
Cancer immunotherapy has steadily progressed during the past decades, with checkpoint
inhibitor therapy becoming the latest and one of the most promising treatments. Despite the …

Chitosan-coated nanodiamonds: Mucoadhesive platform for intravesical delivery of doxorubicin

MS Ali, AA Metwally, RH Fahmy, R Osman - Carbohydrate polymers, 2020 - Elsevier
Nanodiamonds (NDs) are an emerging delivery system with a massive surface area
qualifying them for efficient loading with various drugs. However, NDs easily scavenge ions …

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model

VA Trivillin, YV Langle, MA Palmieri… - The British Journal of …, 2021 - academic.oup.com
We previously demonstrated, for the first time, the abscopal effect of Boron Neutron Capture
Therapy (BNCT) in an ectopic model of syngeneic colon cancer in BDIX rats. Objective: The …

Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status

DT de Oliveira, ALV Sávio… - Journal of …, 2017 - Springer
Silibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have
shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we …

High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer …

F Wang, G Zhang, T Xu, J Ma, J Wang, S Liu… - Journal of Experimental …, 2024 - Springer
Background Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral
resection of bladder tumor (TURBT) followed by intravesical instillation of chemotherapy or …