An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds

O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …

The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

NF Nadur, LL de Azevedo, L Caruso… - European Journal of …, 2021 - Elsevier
Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a
critical role in the indirect regulation of several intracellular metabolism pathways through …

Recent advances in nanocatalyzed synthesis of triazoles and tetrazoles and their biological studies

PM Jadhav, AB Kanagare, AB Dhirbassi… - …, 2022 - taylorfrancis.com
Triazoles and tetrazoles are biologically significant five-membered heterocyclic that
constitute the skeletons of several commercially marketed drugs and other heterocyclic …

Photoinduced arylation or alkylation of 1, 2, 4-triazine-3, 5 (2 H, 4 H)-diones with hydrazines

Y Pan, Y Zhu, S Li, G Li, Z Ma, Y Qian… - Chemical …, 2024 - pubs.rsc.org
A light-induced method is developed for synthesizing azauracils. This method is
independent from traditional methodology. Remarkably, this reaction can also be powered …

[HTML][HTML] 黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展

李文烨, 翟纳, 巨修练, 刘根炎 - 药学学报, 2021 - html.rhhz.net
黄嘌呤氧化酶抑制剂非布司他是经典的抗痛风药物, 治疗效果显著且耐受性好.
非布司他及其衍生物在结构上可以分为两个主要部分, 分别为取代苯环和羧基取代的五元或六元 …

[PDF][PDF] Beyond the heart-Exploring the therapeutic potential of PDE3 inhibitors

M Trawally - Journal of Research in Pharmacy, 2023 - researchgate.net
Phosphodiesterases (PDEs) consist of an enzyme family of eleven groups responsible for
the hydrolytic breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine …

[PDF][PDF] A review on the recent advancements in biological activity of triazoles and tetrazoles

PM Jadhav, PR Mali - J. Emerg. Technol. Innov. Res., 2022 - academia.edu
Triazoles and tetrazoles are the biologically significant five-membered heterocycles
constituting the skeletons of several commercially marketed drugs and other heterocyclic …

[PDF][PDF] Preparation and biological study of new (Tetrazole, β-Lactam, Thiazolidinedione, Oxazepine, and Imidazole) derive from 2-aminobenzimidazol

MF Hassan, MI Kadhim - researchgate.net
Through this study, a group of heterocyclic compounds represented by a five-membered
ring, seven rings, and a tetracyclic ring, represented by Oxazepine, β-lactam, Thiazolidines …

Novel Dihydrooxadiazinones as PDE3 Inhibitors for Treating Cancer

RW Sabnis - ACS Medicinal Chemistry Letters, 2021 - ACS Publications
Patent Publication Number. WO 2020/157188 A1 Publication Date. August 6, 2020 Priority
Application. US 62/800,075 Priority Date. February 1, 2019 Inventors. Ellermann, M.; Gradl …