Kv channels form voltage-dependent potassium selective pores in the outer cell membrane
and are composed out of four α-subunits, each having six membrane-spanning α-helices …

Current mechanisms of arrhythmogenesis in catecholaminergic polymorphic ventricular
tachycardia (CPVT) require spontaneous Ca2+ release via cardiac ryanodine receptor …

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking
neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes …

The intricate functions of membrane proteins would not be possible without bends or breaks
that are remarkably common in transmembrane helices. The frequent helix distortions are …

Voltage-gated potassium channels form potassium-selective pores in cell membranes. They
open or close in response to changes in the transmembrane potential and are essential for …

Kinks are a structural feature of alpha-helices and many are known to have functional roles.
Kinks have previously tended to be defined in a binary fashion. In this paper we have …

Structural evidence and much experimental data have demonstrated the presence of non-
canonical helical substructures (π and 310) in regions of great functional relevance both in …

Purpose The voltage-gated potassium channel K v 3.2, encoded by KCNC2, facilitates fast-
spiking GABAergic interneurons to fire action potentials at high frequencies. It is pivotal to …

The translocation of α-helix chains through a nanopore is studied through Langevin
dynamics simulations. The α-helix chains exhibit several different characteristics about their …

Voltage-gated potassium (Kv) channels work in concert with other ion channels to determine
the frequency and duration of action potentials in excitable cells. Little is known about Kv3 …