α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer's Disease

DM Perez - International journal of molecular sciences, 2023 - mdpi.com
α1-Adrenergic receptors (ARs) are members of the G-Protein Coupled Receptor superfamily
and with other related receptors (β and α2), they are involved in regulating the sympathetic …

Exploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1, 2, 3-triazol-1-yl) phenyl) …

MH Presa, MJ da Rocha, KNB Ledebuhr… - Behavioural Brain …, 2025 - Elsevier
Abstract 1-(2-(4-(4-ethylphenyl)-1H-1, 2, 3-triazol-1-yl) phenyl) ethanone (ETAP) is a novel
hybrid compound containing 1, 2, 3-triazole and acetophenone. It exhibits antidepressant …

[HTML][HTML] Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids

VAD Holanda, MC Oliveira, ED da Silva Junior… - Brain Research …, 2022 - Elsevier
The benign prostatic hyperplasia (BPH) is the main source of lower urinary tract symptoms.
The BPH is a common age‐dependent disease and tamsulosin is an α 1-adrenoceptor …

The alpha1A antagonist tamsulosin impairs memory acquisition, consolidation and retrieval in a novel object recognition task in mice

VAD Holanda, MC Oliveira, CI de Oliveira Torres… - Behavioural Brain …, 2024 - Elsevier
Tamsulosin is an α 1-adrenoceptor antagonist used to treat benign prostatic hyperplasia.
This drug exhibits high affinity for α 1A-and α 1D-adrenoceptor subtypes, which are also …

[HTML][HTML] High Salt Intake Induces Active Coping Behaviors by Enhancing the Resilience against Psychological Stress in Mice

R Hashimoto, T Murakami, R Kamimura… - Journal of Integrative …, 2022 - imrpress.com
Background: High salt intake increases the active coping behavior during psychological
stress. Acute fear-related severe stress enhances passive coping behavior during …

Mechanizmy komórkowe odpowiedzialne za szybki efekt przeciwdepresyjny i prokognitywny związku HBK-15

K Sałaciak - 2022 - ruj.uj.edu.pl
Obecnie depresja jest drugim po chorobach układu krążenia najpoważniejszym problemem
zdrowotnym na świecie, a według prognoz WHO do 2030 roku będzie na pierwszym …

PV Interneuron-driven Amygdalar Network Dynamics Compute Valence Directionality

E Teboul - 2023 - search.proquest.com
The pursuit of rewards and aversion to punishment constitutes some of the most
fundamental behaviors necessary for organismal survival. Valence assignment, the binary …