Pressing the right buttons: signaling in lymphangiogenesis

S Coso, E Bovay, TV Petrova - Blood, The Journal of the …, 2014 - ashpublications.org
Lymphatic vasculature is increasingly recognized as an important factor both in the
regulation of normal tissue homeostasis and immune response and in many diseases, such …

[HTML][HTML] E2F8 is a potential therapeutic target for hepatocellular carcinoma

Y Lv, J Xiao, J Liu, F Xing - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
E2F transcriptional factors are widely expressed in a number of tissues and organs,
possessing many regulatory functions related to cellular proliferation, differentiation, DNA …

The YAP–TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer

J Song, X Dang, X Shen, Y Liu, J Gu, X Peng… - Journal of Biological …, 2023 - ASBMB
The secreted protein collagen and calcium-binding EGF domain 1 (CCBE1) is critical for
embryonic lymphatic development through its role in the proteolytic activation of mature …

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

B Weijts, E Gutierrez, SK Saikin, AJ Ablooglu… - Nature …, 2018 - nature.com
Arteries and veins are formed independently by different types of endothelial cells (ECs). In
vascular remodeling, arteries and veins become connected and some arteries become …

Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down-regulating pERK1/2-foxm1-MMP2/9 axis and epigenetically …

Z Tai, L Li, G Zhao, JX Liu - Angiogenesis, 2022 - Springer
Molecular transport and cell circulation between tissues and organs through blood and
lymphatic vessels are essential for physiological homeostasis in vertebrates. Despite the …

E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle

J Sun, R Shi, S Zhao, X Li, S Lu, H Bu, X Ma… - Journal of Experimental & …, 2017 - Springer
Background Thyroid cancer is the most common malignancy of endocrine system, and
papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F …

Timed Ang2-targeted therapy identifies the angiopoietin–tie pathway as key regulator of fatal lymphogenous metastasis

N Gengenbacher, M Singhal, C Mogler, L Hai, L Milde… - Cancer discovery, 2021 - AACR
Recent clinical and preclinical advances have highlighted the existence of a previously
hypothesized lymphogenous route of metastasis. However, due to a lack of suitable …

[HTML][HTML] Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition

L Ye, L Guo, Z He, X Wang, C Lin, X Zhang, S Wu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
E2F transcription factors are involved in cell cycle regulation and synthesis of DNA in
mammalian cells, and simultaneously play important roles in the development and …

[HTML][HTML] Whole blood transcript and protein abundance of the vascular endothelial growth factor family relate to cognitive performance

JB Libby, M Seto, OA Khan, D Liu, V Petyuk… - Neurobiology of …, 2023 - Elsevier
The vascular endothelial growth factor (VEGF) family of genes has been implicated in the
clinical development of Alzheimer's Disease (AD). A previous study identified associations …

Esm1 and Stc1 as angiogenic factors responsible for protective actions of adipose-derived stem cell sheets on chronic heart failure after rat myocardial infarction

M Watanabe, H Horie, Y Kurata, Y Inoue, T Notsu… - Circulation …, 2021 - jstage.jst.go.jp
Background: Although adipose-derived stem cell (ADSC) sheets improve the cardiac
function after myocardial infarction (MI), underlying mechanisms remain to be elucidated …