Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome …

JT Szilagyi, V Avula, RC Fry - Current environmental health reports, 2020 - Springer
Abstract Purpose of Review This review summarizes studies highlighting perfluoroalkyl
substances (PFAS) and their effects on the placenta, pregnancy outcomes, and child health …

Developmental origins of disease-crisis precipitates change

C Reichetzeder, SE Dwi Putra, J Li… - Cellular Physiology and …, 2016 - karger.com
The concept of developmental origins of diseases has gained a huge interest in recent years
and is a constantly emerging scientific field. First observations hereof originated from …

Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

SK Berglund, L García-Valdés, FJ Torres-Espinola… - BMC public health, 2016 - Springer
Background Maternal overweight, obesity, and gestational diabetes (GD) have been
negatively associated with offspring development. Further knowledge regarding metabolic …

Molecular pathways in placental-fetal development and disruption

JJ Adibi, Y Zhao, H Koistinen, RT Mitchell… - Molecular and cellular …, 2024 - Elsevier
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

Parental genetic effects on the offspring's phenotype without transmission of the gene itself—pathophysiology and clinical evidence

X Zhang, B Hocher - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Parental genes can influence the phenotype of their offspring through genomic-epigenomic
interactions even without the direct inheritance of specific parental genotypes. Maternal …

[HTML][HTML] Placental pathology and long-term neurodevelopment of very preterm infants

EOG van Vliet, JF de Kieviet, JP van der Voorn… - American journal of …, 2012 - Elsevier
OBJECTIVE: The objective of the study was to compare neonatal morbidity and long-term
neurodevelopmental outcome between very preterm infants with placental underperfusion …

Nuclear peroxisome proliferator-activated receptors (PPARs) as therapeutic targets of resveratrol for autism spectrum disorder

R Barone, R Rizzo, G Tabbì, M Malaguarnera… - International Journal of …, 2019 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
defective social communication and interaction and restricted, repetitive behavior with a …

Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself

B Hocher, YP Lu, C Reichetzeder, X Zhang… - Diabetologia, 2022 - Springer
Aims/hypothesis It was shown that maternal endothelial nitric oxide synthase (eNOS)
deficiency causes fatty liver disease and numerically lower fasting glucose in female wild …

A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission

K Audouze, O Taboureau, P Grandjean - Toxicology and applied …, 2018 - Elsevier
The need to prevent developmental brain disorders has led to an increased interest in
efficient neurotoxicity testing. When an epidemic of microcephaly occurred in Brazil, Zika …

PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus

HA Shawki, EM Abo-Hashem, MM Youssef… - Journal of Diabetes & …, 2022 - Springer
Purpose Diabetes mellitus (DM) is a growing global health concern. Genetic factors play a
pivotal role in the development of diabetes. Therefore, the present work aimed to study the …