Snakebite envenoming
Snakebite envenoming is a neglected tropical disease that kills> 100,000 people and
maims> 400,000 people every year. Impoverished populations living in the rural tropics are …
maims> 400,000 people every year. Impoverished populations living in the rural tropics are …
Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise
J Slagboom, J Kool, RA Harrison… - British journal of …, 2017 - Wiley Online Library
Snake venoms are mixtures of numerous proteinacious components that exert diverse
functional activities on a variety of physiological targets. Because the toxic constituents …
functional activities on a variety of physiological targets. Because the toxic constituents …
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming
Snakebites affect about 1.8 million people annually. The current standard of care involves
antibody-based antivenoms, which can be difficult to access and are generally not effective …
antibody-based antivenoms, which can be difficult to access and are generally not effective …
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming.
The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to …
The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to …
The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics
JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Naja spp. African snakes
A Gómez, A Sánchez, G Durán, M Villalta… - PLOS Neglected …, 2023 - journals.plos.org
Background Envenomations by African snakes represent a high burden in the sub-Sahara
region. The design and fabrication of polyspecific antivenoms with a broader effectiveness …
region. The design and fabrication of polyspecific antivenoms with a broader effectiveness …
Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by …
Snakebite is a global tropical disease that has long had huge implications for human health
and well-being. Despite its long-standing medical importance, it has been the most …
and well-being. Despite its long-standing medical importance, it has been the most …