Circulating adiponectin concentrations are reduced in obese individuals, and this reduction
has been proposed to have a crucial role in the pathogenesis of atherosclerosis and …

Aims There has been growing evidence that adiponectin, tumor necrosis factor-α (TNF-α)
and inflammatory cytokines involved in insulin resistance and may be attractive candidates …

Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its
associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary …

Advancing age is associated with progressive declines in physiological function that lead to
overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological …

There is increasing evidence showing that inflammation is an important pathogenic mediator
of the development of obesity-induced insulin resistance. It is now generally accepted that …

OBJECTIVE There has been growing evidence that inflammatory markers play a role in the
development of type 2 diabetes. We aimed to systematically review prospective studies on …

Obesity is a public health problem that has reached epidemic proportions with an increasing
worldwide prevalence. The global emergence of obesity increases the risk of developing …

In 1998, the American Heart Association convened Prevention Conference V to examine
strategies for the identification of high-risk patients who need primary prevention. Among the …

Observational epidemiological studies suffer from many potential biases, from confounding
and from reverse causation, and this limits their ability to robustly identify causal …

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in
diabetic patients. This should have been an important clue to link inflammation to the …