Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho

S Yamada, CM Giachelli - Bone, 2017 - Elsevier
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …

Vascular calcification: pathobiological mechanisms and clinical implications

RC Johnson, JA Leopold, J Loscalzo - Circulation research, 2006 - Am Heart Assoc
Once thought to result from passive precipitation of calcium and phosphate, it now appears
that vascular calcification is a consequence of tightly regulated processes that culminate in …

Loss of junctional adhesion molecule a promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol

K Rahman, C Desai, SS Iyer, NE Thorn, P Kumar, Y Liu… - Gastroenterology, 2016 - Elsevier
Background & Aims There is evidence from clinical studies that compromised intestinal
epithelial permeability contributes to the development of nonalcoholic steatohepatitis …

The role of phosphate in kidney disease

MG Vervloet, S Sezer, ZA Massy, L Johansson… - Nature Reviews …, 2017 - nature.com
The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Arterial stiffness: a focus on vascular calcification and its link to bone mineralization

Y Chen, X Zhao, H Wu - Arteriosclerosis, thrombosis, and vascular …, 2020 - Am Heart Assoc
This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …

Association of disorders in mineral metabolism with progression of chronic kidney disease

S Schwarz, BK Trivedi, K Kalantar-Zadeh… - Clinical journal of the …, 2006 - journals.lww.com
Abnormalities of mineral metabolism are associated with increased mortality in patients with
ESRD, but their effects in predialysis chronic kidney disease (CKD) are less well …

[HTML][HTML] Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin

MM El-Abbadi, AS Pai, EM Leaf, HY Yang, BA Bartley… - Kidney international, 2009 - Elsevier
Arterial medial calcification is a major complication in patients with chronic kidney disease
and is a strong predictor of cardiovascular and all-cause mortality. We sought to determine …

[HTML][HTML] Pathogenesis of vascular calcification in chronic kidney disease

M Cozzolino, D Brancaccio, M Gallieni, E Slatopolsky - Kidney international, 2005 - Elsevier
Pathogenesis of vascular calcification in chronic kidney disease. Background
Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of …

[HTML][HTML] Aortic calcification

RW Jayalath, SH Mangan, J Golledge - European Journal of Vascular and …, 2005 - Elsevier
OBJECTIVES: Vascular calcification is a complicating factor observed in advanced
atherosclerosis. This review summarises the present knowledge regarding abdominal aortic …

Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease

H Vlassara, J Uribarri, W Cai, S Goodman… - Clinical Journal of the …, 2012 - journals.lww.com
Results Sevelamer carbonate reduced HbA1c, serum methylglyoxal, serum ε N-
carboxymethyl-lysine, triglycerides, and 8-isoprostanes. Total cholesterol and fibroblast …