Modeling and Simulations in Latin-American Generic Markets: Perspectives from Chilean Local Industry, Regulatory Agency, and Academia

MA García, C Paulos, M Ibarra Viñales… - Molecular …, 2024 - ACS Publications
In the last 20 years, modeling and simulations (M&S) have gained increased attention in
pharmaceutical sciences. International industry and world-reference agencies have used …

In vitro prediction of in vivo absorption of ibuprofen from suspensions through rational choice of dissolution conditions

M Hofmann, MA García, J Al-Gousous… - European Journal of …, 2020 - Elsevier
Two ibuprofen suspension formulations were investigated for their dissolution in various
bicarbonate, phosphate and acetate buffers. Phosphate and acetate gave faster release …

[HTML][HTML] Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics

PD Sinko, L Parker, LP Wittberg… - International Journal of …, 2024 - Elsevier
Abstract Dissolution-permeation (D/P) experiments are widely used during preclinical
development due to producing results with better predictability than traditional monophasic …