Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances

SB Ganorkar, Y Vander Heyden - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …

[HTML][HTML] An insight into new strategies and targets to combat antifungal resistance: A comprehensive review

D Nahar, P Mohite, A Lonkar, VR Chidrawar… - European Journal of …, 2024 - Elsevier
Antifungal drugs target specific components or processes within fungal cells to prevent or
eliminate their growth. Various antifungal targets exist, including the cell membrane …

[HTML][HTML] Molecular docking simulation combining with multi-spectroscopy techniques clarify how small molecule ligands bind to biomacromolecule: Myosin and …

H Liu, X Wei, R Nie, C Xiang, T Hui, S Li, Z Wang… - Lwt, 2022 - Elsevier
The protein is an ideal food matrix binding volatile compounds. However, the synergistic
effects between the protein rheological behavior and protein-ligand interactions on the small …

Profiling of antifungal activities and in silico studies of natural polyphenols from some plants

B Khanzada, N Akhtar, MK Okla, SA Alamri… - Molecules, 2021 - mdpi.com
A worldwide increase in the incidence of fungal infections, emergence of new fungal strains,
and antifungal resistance to commercially available antibiotics indicate the need to …

Utility of itraconazole and terbinafine in mucormycosis: a proof-of-concept analysis

P Gupta, HS Malhotra, P Saxena… - Journal of …, 2022 - journals.sagepub.com
An epidemic of mucormycosis followed the second wave of COVID 19 in the state of Uttar
Pradesh, India in May 2021. This epidemic, however, had additional challenges to offer in …

Comprehensive binding analysis of glycated myosin with furan derivatives via glucose by means of multi-spectroscopy techniques and molecular docking simulation

H Liu, J Li, F Wang, X Sun, D Liu, Z Wang… - Food Research …, 2023 - Elsevier
Myosin is an ideal binding receptor for aroma compounds and its functional properties are
easily affected by glucose. The study comprehensively clarified the effects of glucose …

Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis

M Tanwar, A Singh, TP Singh, S Sharma… - ACS Infectious …, 2024 - ACS Publications
Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19
pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to …

Development of microemulgel formulations with varied permeation enhancers for transungual delivery of luliconazole in onychomycosis management

Y Giri, S Habibullah, PK Dixit, G Mahalik… - Colloids and Surfaces B …, 2024 - Elsevier
Luliconazole-loaded microemulgels containing different permeation enhancers were
formulated for transungual drug delivery for the management of onychomycosis …

Hs-dti: Drug-target interaction prediction based on hierarchical networks and multi-order sequence effect

X Gong, M Liu, H Sun, M Li, Q Liu - 2022 IEEE International …, 2022 - ieeexplore.ieee.org
Computer-aided drug design utilizes powerful computers to simulate the tasks in drug
design, which could significantly accelerate drug development and reduce cost …

Unleashing the potential of vanillic acid: A new twist on nature's recipe to fight inflammation and circumvent azole-resistant fungal infections

FA Khan, R Irshad, N Tanveer, S Yaqoob, R Ali… - Bioorganic …, 2024 - Elsevier
Vanillic acid (VA)—a naturally occurring phenolic compound in plants—is not only used as a
flavoring agent but also a prominent metabolite post tea consumption. VA and its associated …