The p53 family member p73 in the regulation of cell stress response
JM Rozenberg, S Zvereva, A Dalina, I Blatov, I Zubarev… - Biology direct, 2021 - Springer
During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …
Epithelial–mesenchymal transition in ovarian carcinoma
B Davidson, CG Tropé, R Reich - Frontiers in oncology, 2012 - frontiersin.org
Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying
within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is …
within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is …
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
E Suberbielle, B Djukic, M Evans, DH Kim… - Nature …, 2015 - nature.com
Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may
contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced …
contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced …
Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer
W Su, M Xu, X Chen, N Chen, J Gong, L Nie, L Li, X Li… - Molecular cancer, 2017 - Springer
Background Emerging studies show that long noncoding RNAs (lncRNAs) play important
roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) …
roles in carcinogenesis and cancer progression. The lncRNA ZEB1 antisense 1 (ZEB1-AS1) …
Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer
MX Liu, MKY Siu, SS Liu, JWP Yam, HYS Ngan… - …, 2013 - pmc.ncbi.nlm.nih.gov
Epithelial ovarian cancer is a highly lethal and aggressive gynecological malignancy. The
high mortality rate is due in part to the fact that many advanced cancer patients become …
high mortality rate is due in part to the fact that many advanced cancer patients become …
p73 in Cancer
p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct
isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows …
isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows …
Alterations of p63 and p73 in human cancers
K Inoue, EA Fry - Mutant p53 and MDM2 in Cancer, 2014 - Springer
Abstract p53 and its related genes, p63 and p73 constitute the p53 gene family. While p53 is
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …
Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)
BS Tan, KH Tiong, HL Choo, F Fei-Lei Chung… - Cell death & …, 2015 - nature.com
Abstract p53 is the most frequently mutated tumor-suppressor gene in human cancers.
Unlike other tumor-suppressor genes, p53 mutations mainly occur as missense mutations …
Unlike other tumor-suppressor genes, p53 mutations mainly occur as missense mutations …
CYP2S1 and CYP2W1 mediate 2-(3, 4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells
BS Tan, KH Tiong, A Muruhadas, N Randhawa… - Molecular cancer …, 2011 - AACR
Abstract Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203; NSC 703786)
and 2-(3, 4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610; NSC 721648) are antitumor …
and 2-(3, 4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610; NSC 721648) are antitumor …