The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-
2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study …

Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …

The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

This meeting was organized by The Transplantation Society with the assistance of an
unconditional education grant from CSL Behring. CSL Behring had no involvement in the …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …