Background In patient care, data are historically generated and stored in heterogeneous
databases that are domain specific and often noninteroperable or isolated. As the amount of …

In the past decade, cancer research has seen an increasing trend towards high-throughput
techniques and translational approaches. The increasing availability of assays that utilise …

Data from the electronic medical record comprise numerous structured but uncoded ele-
ments, which are not linked to standard terminologies. Reuse of such data for secondary …

The Learning Health System (LHS) describes linking routine healthcare systems directly
with both research translation and knowledge translation as an extension of the evidence …

This article presents the history, contents, structures, functions, and applications of the
International Classification of Diseases (ICD), which is a global standard maintained by the …

The translational research community, in general, and the Clinical and Translational
Science Awards (CTSA) community, in particular, share the vision of repurposing EHRs for …

Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on
“Managing Interoperability and Complexity in Health Systems”. Background: Primary care …

The provenance of a piece of data refers to knowledge about its origin, in terms of the
entities and actors involved in its creation, eg data sources used, operations carried out on …

Abstract Objective The Learning Health System (LHS) requires integration of research into
routine practice.'eSource'or embedding clinical trial functionalities into routine electronic …

Introduction The learning health system (LHS) community has taken up the challenge of
bringing the complex relationship between clinical research and practice into this brave new …