The bromodomain and extra-terminal domain (BET) family: functional anatomy of BET paralogous proteins
Y Taniguchi - International journal of molecular sciences, 2016 - mdpi.com
The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …
BET domain co-regulators in obesity, inflammation and cancer
AC Belkina, GV Denis - Nature reviews Cancer, 2012 - nature.com
The bromodomain is a highly conserved motif of 110 amino acids that is bundled into four
anti-parallel α-helices and found in proteins that interact with chromatin, such as …
anti-parallel α-helices and found in proteins that interact with chromatin, such as …
Clinical trials for BET inhibitors run ahead of the science
Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins
have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4 …
have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4 …
KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
D Ganem - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi
sarcoma–associated herpesvirus [KSHV]) is one of the great successes of contemporary …
sarcoma–associated herpesvirus [KSHV]) is one of the great successes of contemporary …
Viral latency and its regulation: lessons from the γ-herpesviruses
SH Speck, D Ganem - Cell host & microbe, 2010 - cell.com
Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …
BET proteins: Biological functions and therapeutic interventions
J Guo, Q Zheng, Y Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
G Zhang, B Chan, N Samarina… - Proceedings of the …, 2016 - National Acad Sciences
The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …
Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis
KW Wen, B Damania - Cancer letters, 2010 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus
belonging to the γ-herpesvirinae subfamily. KSHV has been associated with the …
belonging to the γ-herpesvirinae subfamily. KSHV has been associated with the …
KSHV LANA—the master regulator of KSHV latency
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse
E Shang, X Wang, D Wen, DA Greenberg… - Developmental …, 2009 - Wiley Online Library
Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse -
Shang - 2009 - Developmental Dynamics - Wiley Online Library Skip to Article Content Skip to …
Shang - 2009 - Developmental Dynamics - Wiley Online Library Skip to Article Content Skip to …