[HTML][HTML] Combination therapy and phytochemical-loaded nanosytems for the treatment of neglected tropical diseases

J Soto-Sánchez, G Garza-Treviño - Pharmaceutics, 2024 - mdpi.com
Background: Neglected tropical diseases (NTDs), including leishmaniasis, trypanosomiasis,
and schistosomiasis, impose a significant public health burden, especially in developing …

Herbal Products‐Powered Thermosensitive Hydrogel with Phototherapy and Microenvironment Reconstruction for Accelerating Multidrug‐Resistant Bacteria‐Infected …

G Zhao, G Lu, H Fan, L Wei, Q Yu, M Li… - Advanced …, 2024 - Wiley Online Library
Wound healing and infection remain significant challenges due to the ineffectiveness
against multidrug‐resistant (MDR) bacteria and the complex oxidative wound …

High-quality reference genome of Fasciola gigantica: Insights into the genomic signatures of transposon-mediated evolution and specific parasitic adaption in tropical …

X Luo, K Cui, Z Wang, Z Li, Z Wu… - PLoS Neglected …, 2021 - journals.plos.org
Fasciola gigantica and Fasciola hepatica are causative pathogens of fascioliasis, with the
widest latitudinal, longitudinal, and altitudinal distribution; however, among parasites, they …

Antiparasitic effects of selected isoflavones on flatworms

D Faixová, G Hrčková, TM Kubašková, D Mudroňová - Helminthologia, 2021 - sciendo.com
Medicinal plants have been successfully used in the ethno medicine for a wide range of
diseases since ancient times. The research on natural products has allowed the discovery of …

In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni

KEDM Mokbel, IR Baiuomy, AEHA Sabry… - Scientific reports, 2020 - nature.com
Schistosomiasis is a serious parasitic infection affecting millions worldwide. This study
aimed to explore the anti-schistosomal activity of curcumin and curcumin loaded gold …

Anthelmintic effects of some medicinal plants on different life stages of Fasciola hepatica: Evidence on oxidative stress biomarkers, and DNA damage

M Allahyari, F Malekifard… - PLOS Neglected Tropical …, 2024 - journals.plos.org
Fasciolosis caused by Fasciola hepatica is a major public health and economic problem
worldwide. Due to the lack of a successful vaccine and emerging resistance to the drug …

Oxidative status and changes in the adenosine deaminase activity in experimental host infected with tropical liver fluke, Fasciola gigantica

A Rehman, L Rehman, R Ullah, MA Beg, MAH Khan… - Acta Tropica, 2021 - Elsevier
Fine tuning of the metabolic, physiological and immunological cues along with interplay
between the biomolecules of the host and the parasite could be responsible for the …

PLGA-Based Nanoparticles of Curcumin for Effective Anthelmintic Therapy Against Fasciola gigantica

R Ullah, A Rehman, L Rehman, MA Beg, B Choudhary… - BioNanoScience, 2025 - Springer
Curcumin, a polyphenol found in Curcuma longa, exhibits diverse biological activities,
including antioxidant, anti-inflammatory, anti-infectious, and anti-carcinogenic properties. To …

In vitro assessment of the anthelmintic activity of copper oxide and zinc oxide nanoparticles on egg and adult stages of Fasciola hepatica: evidence on oxidative …

A Ravvaz, F Malekifard, B Esmaeilnejad - BMC Veterinary Research, 2024 - Springer
Objectives Fasciolosis is of significant economic and public health importance worldwide.
The lack of a successful vaccine and emerging resistance in flukes to the drug of choice …

Thymoquinone effect on the Dictyostelium discoideum model correlates with functional roles for glutathione S-transferases in eukaryotic proliferation, chemotaxis, and …

N Alsaffar, Y Fang, E Walters - Plos one, 2023 - journals.plos.org
An increasing body of literature demonstrates the therapeutic relevance of polyphenols in
eukaryotic cell and animal model studies. The phase II glutathione S-transferases (GST) …