Cellular responses to the efferocytosis of apoptotic cells
The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …
[HTML][HTML] Boosting inflammation resolution in atherosclerosis: the next frontier for therapy
Defective inflammation resolution is the underlying cause of prevalent chronic inflammatory
diseases, such as arthritis, asthma, cancer, and neurodegenerative and cardiovascular …
diseases, such as arthritis, asthma, cancer, and neurodegenerative and cardiovascular …
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
Atherothrombotic vascular disease is often triggered by a distinct type of atherosclerotic
lesion that displays features of impaired inflammation resolution, notably a necrotic core and …
lesion that displays features of impaired inflammation resolution, notably a necrotic core and …
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
The acute inflammatory response requires a coordinated resolution program to prevent
excessive inflammation, repair collateral damage, and restore tissue homeostasis, and …
excessive inflammation, repair collateral damage, and restore tissue homeostasis, and …
Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis
C Lastrucci, A Bénard, L Balboa, K Pingris, S Souriant… - Cell research, 2015 - nature.com
The human CD14+ monocyte compartment is composed by two subsets based on CD16
expression. We previously reported that this compartment is perturbed in tuberculosis (TB) …
expression. We previously reported that this compartment is perturbed in tuberculosis (TB) …
Urinary soluble CD163: a novel noninvasive biomarker of activity for lupus nephritis
JM Mejia-Vilet, XL Zhang, C Cruz… - Journal of the …, 2020 - journals.lww.com
Background Clinical distinction between patients with lupus nephritis who have active
inflammation or chronic kidney damage is challenging. Studies have shown soluble CD163 …
inflammation or chronic kidney damage is challenging. Studies have shown soluble CD163 …
CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis
G Olmes, M Büttner-Herold, F Ferrazzi, L Distel… - Arthritis research & …, 2016 - Springer
Background The role of macrophages in the pathogenesis of lupus nephritis, in particular
their differentiation to a certain subtype (eg, M1-or M2-like) modulating the inflammatory …
their differentiation to a certain subtype (eg, M1-or M2-like) modulating the inflammatory …
Changes in transcriptome of macrophages in atherosclerosis
DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2015 - Wiley Online Library
Macrophages display significant phenotypic heterogeneity. Two growth factors, macrophage
colony‐stimulating factor and chemokine (C‐X‐C motif) ligand 4, drive terminal …
colony‐stimulating factor and chemokine (C‐X‐C motif) ligand 4, drive terminal …
Association of urine sCD163 with proliferative lupus nephritis, fibrinoid necrosis, cellular crescents and intrarenal M2 macrophages
CD163 is a marker for alternatively activated macrophages, which have been implicated in
the pathogenesis of lupus nephritis (LN). In our preliminary screening of urine proteins in …
the pathogenesis of lupus nephritis (LN). In our preliminary screening of urine proteins in …
Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE
Systemic lupus erythematosus (SLE) is characterized by antibody-mediated chronic
inflammation in the kidney, lung, skin, and other organs to cause inflammation and damage …
inflammation in the kidney, lung, skin, and other organs to cause inflammation and damage …