Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …

Abstract LC3-associated phagocytosis (LAP) is a novel form of non-canonical autophagy
where LC3 (microtubule-associated protein 1A/1B–light chain 3) is conjugated to …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

Mycobacterium tuberculosis is an intracellular pathogen persisting within phagosomes
through interference with phagolysosome biogenesis. Here we show that stimulation of …