Genome‐wide association and polygenic risk score estimation of type 2 diabetes mellitus in Kinh Vietnamese—A pilot study

TP Mai, BA Luong, PT Ma, TV Tran… - Journal of Cellular …, 2024 - Wiley Online Library
A genome‐wide association study (GWAS) is a powerful tool in investigating genetic
contribution, which is a crucial factor in the development of complex multifactorial diseases …

Exome-based gene panel analysis in a cohort of acute juvenile ischemic stroke patients:relevance of NOTCH3 and GLA variants

J Härtl, J Hartberger, S Wunderlich, I Cordts… - Journal of …, 2023 - Springer
Background Genetic variants are considered to have a crucial impact on the occurrence of
ischemic stroke. In clinical routine, the diagnostic value of next-generation sequencing …

Clinical and genetic analysis of Vietnamese patients diagnosed with early‐onset Parkinson's disease

MD Do, TN Tran, AB Luong, LHG Le… - Brain and …, 2023 - Wiley Online Library
Background Genetic factors play a crucial role in the pathogenesis of Parkinson's disease
(PD). However, no comprehensive study has described genetic alterations in Vietnamese …

Association of KCNJ11 and ABCC8 single-nucleotide polymorphisms with type 2 diabetes mellitus in a Kinh Vietnamese population

NQ Tran, SD Truong, PT Ma, CK Hoang, BH Le… - Medicine, 2022 - journals.lww.com
Type 2 diabetes mellitus (T2DM) is a genetically influenced disease, but few studies have
been performed to investigate the genetic basis of T2DM in Vietnamese subjects. Thus, the …

Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C

M Farajzadeh-Dehkordi, L Mafakher, A Harifi… - Plos one, 2023 - journals.plos.org
Protein C (PC) is a vitamin K-dependent factor that plays a crucial role in controlling
anticoagulant processes and acts as a cytoprotective agent to promote cell survival. Several …

Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction

DC Tran, LHG Le, TT Thai, SV Hoang… - Frontiers in …, 2023 - frontiersin.org
Background The severity of coronary artery disease is a prognostic factor for major adverse
cardiovascular events in patients diagnosed with acute myocardial infarction. ACE I/D …

Genotype–phenotype characteristics of Vietnamese patients diagnosed with Charcot–Marie–Tooth disease

TH Nguyen‐Le, MD Do, LHG Le, QNN Nhat… - Brain and …, 2022 - Wiley Online Library
Abstract Background Charcot–Marie‐Tooth (CMT) disease is one of the most common
hereditary neuropathies. Identifying causative mutations in CMT is essential as it provides …

Association Between AGT M235T and Left Ventricular Mass in Vietnamese Patients Diagnosed With Essential Hypertension

TT Tran, TP Mai, HCB Tran, LHG Le, HA Vu… - Frontiers in …, 2021 - frontiersin.org
Background: Increasing left ventricular mass in hypertensive patients is an independent
prognostic marker for adverse cardiovascular outcomes. Genetic factors have been shown …

Molecular characteristics of young‐onset colorectal cancer in Vietnamese patients

MD Do, TH Nguyen, KT Le, LHG Le… - Asia‐Pacific Journal …, 2022 - Wiley Online Library
Background Colorectal cancer (CRC) is one of the most common cancer globally.
Understanding the genetic characteristics of CRC is essential for appropriate treatment and …

Effect of AGTR1 A1166C genetic polymorphism on coronary artery lesions and mortality in patients with acute myocardial infarction

DC Tran, LHG Le, TT Thai, S Van Hoang, MD Do… - Plos one, 2024 - journals.plos.org
The pathogenesis and prognosis of patients with acute myocardial infarction (AMI) may be
influenced by both genetic and environmental factors. Findings on the relationship of …