Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Production of NO from arginine and molecular oxygen is a complex chemical reaction
unique to biology. Our understanding of the chemical and regulation mechanisms of the NO …

Calmodulin is a prototypical and versatile Ca 2+ sensor with EF hands as its high-affinity Ca
2+ binding domains. Calmodulin is present in all eukaryotic cells, mediating Ca 2+ …

Mammalian nitric oxide synthase (NOS), a flavo-hemoprotein, tightly regulates nitric oxide
(NO) synthesis and thereby its dual biological activities as a key signaling molecule for …

Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal disease
encountered in the premature infant. Although the inciting events leading to NEC remain …

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in
physiological activities of various organ systems. Nitric oxide is produced in the endocrine …

Under many inflammatory contexts, such as tumor progression, systemic and peripheral
immune response is tailored by reactive nitrogen species (RNS)-dependent post …

Background and Purpose Reduced NO levels and activity are signs of endothelial
dysfunction, which is important in mediating BP changes. Previously, we demonstrated that …

Nitric oxide (NO) generated from nitric oxide synthase (NOS) exerts a dichotomous effect in
melanoma, suppressing or promoting tumor progression. This dichotomy is thought to …

Oxidative stress resulting from accumulation of reactive oxygen, nitrogen, and halogen
species (ROS, RNS, and RHS, respectively) causes the damage of cells and biomolecules …