Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Tropomodulins are a family of four proteins (Tmods 1–4) that cap the pointed ends of actin
filaments in actin cytoskeletal structures in a developmentally regulated and tissue‐specific …

Nemaline myopathy (NM) is a genetic muscle disorder characterized by muscle dysfunction
and electron-dense protein accumulations (nemaline bodies) in myofibers. Pathogenic …

We focus here on the modulation of thin filament activity by cardiac troponin I
phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a …

In striated muscle, the actin cytoskeleton is differentiated into myofibrils. Actin and myosin
filaments are organized in sarcomeres and specialized for producing contractile forces …

Cytoskeletal structures characterized by actin filaments with uniform lengths, including the
thin filaments of striated muscles and the spectrin-based membrane skeleton, use barbed …

Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV)
translocation and fusion with the plasma membrane (PM). Using mass spectrometry, we …

Maintenance of skeletal muscle quantity and quality is essential to ensure various vital
functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and …

Regulating the thin-filament length in muscle is crucial for controlling the number of myosin
motors that generate power. The giant protein nebulin forms a long slender filament that …

The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …