For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

Caffeine is the most widely consumed psychoactive substance in the world. It is readily
available in coffee and other foods and beverages, and is used to mitigate sleepiness …

With the advancement of systems biology research, we have already seen great progress in
pharmacology studies, especially in network pharmacology. Network pharmacology has …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

The classic endogenous somnogen adenosine promotes sleep via A 1 and A 2A receptors.
In this chapter, we present an overview of the current knowledge regarding the regulation of …

Abstract Purpose of Review This article reviews the neurobehavioral deficits resulting from
sleep loss in adults, various countermeasures to mitigate these effects, and biomarkers to …

An intricate interplay between circadian and sleep–wake homeostatic processes regulate
cognitive performance on specific tasks, and individual differences in circadian preference …

Some individuals are able to successfully reach very old ages, reflecting higher adaptation
against age-associated effects. Sleep is one of the processes deeply affected by aging; …

Research evidence increasingly points to the large impact of sleep disturbances on public
health. Many aspects of sleep are heritable and genes influencing traits such as timing, EEG …