Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Fibronectin (FN) is a major extracellular matrix (ECM) protein involved in a wide range of
physiological processes, including cell migration. These FN-mediated cell migration events …

Aging is a strong risk factor and an independent prognostic factor for progressive human
idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis …

Changes in the oxidative (redox) environment accompany idiopathic pulmonary fibrosis
(IPF). S-glutathionylation of reactive protein cysteines is a post-translational event that …

Cell–matrix interactions govern cell behavior and tissue function by facilitating transduction
of biomechanical cues. Engineered tissues often incorporate these interactions by …

Mechanotransduction is widely used to guide cell fate in hydrogels. Traditionally, hydrogels
contain adhesive ligands that dynamically bond with cells to stimulate biochemical signaling …

Background Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular
matrix (ECM) remodeling, herein ECM degradation. Fibronectin (FN) is an important …

Nature has endowed us with some complex enzymes capable of utilizing proteins as their
substrates to generate functional proteins through post-translational modification. However …

Increased myeloperoxidase (MPO) expression and activity are associated with
atherosclerotic disease in patients with chronic kidney disease (CKD). However, the causal …

Diversity in the biochemical workhorses of the cell—that is, proteins—is achieved by the
innumerable permutations offered primarily by the 20 canonical L‐amino acids prevalent in …