The spread of antibiotic resistance genes in vivo model

S Tao, H Chen, N Li, T Wang… - Canadian Journal of …, 2022 - Wiley Online Library
Infections caused by antibiotic‐resistant bacteria are a major public health threat. The
emergence and spread of antibiotic resistance genes (ARGs) in the environment or clinical …

Chitinases as key virulence factors in microbial pathogens: understanding their role and potential as therapeutic targets

GJ Jeong, F Khan, N Tabassum, YM Kim - International Journal of …, 2023 - Elsevier
Chitinases are crucial for the survival of bacterial and fungal pathogens both during host
infection and outside the host in the environment. Chitinases facilitate adhesion onto host …

[HTML][HTML] Salmonella typhimurium screen identifies shifts in mixed-acid fermentation during gut colonization

BD Nguyen, A Sintsova, C Schubert, A Sichert… - Cell host & …, 2024 - cell.com
How enteric pathogens adapt their metabolism to a dynamic gut environment is not yet fully
understood. To investigate how Salmonella enterica Typhimurium (S. Tm) colonizes the gut …

Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders

SJ Ruddle, LM Massis, AC Cutter, DM Monack - Cell Host & Microbe, 2023 - cell.com
The molecular understanding of host-pathogen interactions in the gastrointestinal (GI) tract
of superspreader hosts is incomplete. In a mouse model of chronic, asymptomatic …

Bacterial chitinases and their role in human infection

JR Devlin, J Behnsen - Infection and Immunity, 2023 - Am Soc Microbiol
It has been widely appreciated that numerous bacterial species express chitinases for the
purpose of degrading environmental chitin. However, chitinases and chitin-binding proteins …

Sodium Humate-Derived Gut Microbiota Ameliorates Intestinal Dysfunction Induced by Salmonella Typhimurium in Mice

D Wang, Y Zheng, Y Fan, Y He, K Liu… - Microbiology …, 2023 - Am Soc Microbiol
Salmonella is a foodborne pathogen that is one of the main causes of gastroenteric disease
in humans and animals. As a natural organic substance, sodium humate (HNa) possesses …

Chitinase A, a tightly regulated virulence factor of Salmonella enterica serovar Typhimurium, is actively secreted by a Type 10 Secretion System

L Krone, L Faass, M Hauke, C Josenhans… - PLoS …, 2023 - journals.plos.org
As a facultative intracellular pathogen, Salmonella enterica serovar Typhimurium is one of
the leading causes of food-borne diseases in humans. With the ingestion of fecal …

[HTML][HTML] Esculetin Combats Multidrug-Resistant Salmonella Infection and Ameliorates Intestinal Dysfunction via the Nrf2 Pathway

W Xu, W Ding, L Jia, K Zhu, Q Luo - Antioxidants, 2024 - mdpi.com
The increasing incidence of multidrug-resistant (MDR) Salmonella enterica serovar
Typhimurium (S. Tm), known for causing invasive enteric infections, presents a significant …

Human gut metagenomes encode diverse GH156 sialidases

E Mann, S Shekarriz, MG Surette - Applied and Environmental …, 2022 - Am Soc Microbiol
The intestinal lining is protected by a mucous barrier composed predominantly of complex
carbohydrates. Gut microbes employ diverse glycoside hydrolases (GHs) to liberate …

Exploring roles of the chitinase ChiC in modulating Pseudomonas aeruginosa virulence phenotypes

PKT Edvardsen, F Askarian, R Zurich… - Microbiology …, 2024 - Am Soc Microbiol
Chitinases are ubiquitous enzymes involved in biomass degradation and chitin turnover in
nature. Pseudomonas aeruginosa (PA), an opportunistic human pathogen, expresses ChiC …