A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials

Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Lawsone in organic synthesis

AK Jordão, MD Vargas, AC Pinto, FC da Silva… - RSC …, 2015 - pubs.rsc.org
Lawsone (1) is a special naphthoquinone that is useful for many applications in various
scientific and technological fields. For over 100 years, it has been used as the starting …

Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites

R Rani, K Sethi, S Kumar, RS Varma… - Chemical Biology & …, 2022 - Wiley Online Library
Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Chemoselective synthesis of mannich adducts from 1, 4-naphthoquinones and profile as autophagic inducers in oral squamous cell carcinoma

AA Borges, MP de Souza, ACC da Fonseca… - Molecules, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for
approximately 90% of all oral cancers, and is the eighth most common cancer in men …

Design and synthesis of a new series of 3, 5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis

R da Rosa, MH de Moraes, LA Zimmermann… - European journal of …, 2017 - Elsevier
Chagas disease and leishmaniasis are neglected tropical diseases (NTDs) endemic in
developing countries. Although there are drugs available for their treatment, efforts on …

1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line

AJ de Sousa Portilho, EL da Silva… - International Journal of …, 2022 - mdpi.com
The multidrug resistance (MDR) phenotype is one of the major obstacles in the treatment of
chronic myeloid leukemia (CML) in advantage stages such as blast crisis. In this scenario …

Semisynthetic and newly designed derivatives based on natural chemical scaffolds: moving beyond natural products to fight Trypanosoma cruzi

R da Rosa, EP Schenkel, LS Campos Bernardes - Phytochemistry reviews, 2020 - Springer
Secondary metabolites obtained from natural sources are medicinally relevant molecules.
About one-third of all FDA-approved drugs are derived from or based on natural products …

Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green, and Efficient Access to Cytotoxic Compounds

EBT Diogo, FG Delolo, GAP Graça… - European Journal of …, 2023 - Wiley Online Library
Undivided electrochemical cells enable economical preparation of sulphur‐containing
naphthoquinones through electrochemical sulphenylation of quinoidal compounds. The …

A comprehensive review on potential candidates for the treatment of chagas disease

S Pathak, M Bhardwaj, N Agrawal… - Chemical Biology & …, 2023 - Wiley Online Library
Twenty different infectious disorders induced by bacteria, viruses, and parasites are
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …