Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Hydroethanolic extract of Gentiana kurroo Royle rhizome ameliorates ethanol-induced liver injury by reducing oxidative stress, inflammation and fibrogenesis in rats

P Choubey, V Sharma, R Joshi, A Upadhyaya… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Gentiana kurroo Royle is a medicinal plant
mentioned as Traymana in Ayurveda. In the folklore, it is used to cure fever, stomach ache …

UPLC-Q-TOF-MS based investigation into the bioactive compounds and molecular mechanisms of Lamiophlomis Herba against hepatic fibrosis

J Chen, J Ge, W Chen, Y Zhao, T Song, K Fu, X Li… - Phytomedicine, 2023 - Elsevier
Abstract Background Lamiophlomis Herba (LH) is a valuable traditional medicinal plant
found on the Qinghai-Tibetan Plateau that promotes blood circulation, removes blood stasis …

Catechins prevent obesity-induced kidney damage by modulating PPARγ/CD36 pathway and gut-kidney axis in rats

V Patial, S Katoch, J Chhimwal, G Dadhich, V Sharma… - Life Sciences, 2023 - Elsevier
Obesity is an epidemic and a growing public health concern worldwide. It is one of the
significant risk factors for developing chronic kidney disease. In the present study, we …

Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation

S Katoch, J Chhimwal, D Kumar, V Patial - Phytomedicine, 2025 - Elsevier
Background Non-alcoholic steatohepatitis (NASH) has become a serious public health
concern with high global prevalence. The lack of safe and efficient treatment for the …

潜在抗肝纤维化药物与靶点相关信号通路研究进展.

周鑫, 王智, 何雪茹, 付裕豪, 荀雪姣… - Journal of Clinical …, 2023 - search.ebscohost.com
肝纤维化是慢性肝病进展为肝硬化甚至肝癌的关键一步. 近年来, 大量研究表明了干预肝纤维化
进程的必要性, 各种抗肝纤维化药物及活性成分相继被发现. 非编码RNA 在调解肝纤维化进程中 …

Research Progress on Natural Products Alleviating Liver Inflammation and Fibrosis via NF‐κB Pathway

X Li, S Li, N Li - Chemistry & Biodiversity - Wiley Online Library
Liver fibrosis is a key pathological process in chronic liver diseases, regulated by various
cytokines and signaling pathways. Among these, the nuclear factor kappa‐light‐chain …

Research advances in signaling pathways associated with potential anti-liver fibrosis drugs and targets

Z Xin, HE Xueru, FU Yuhao, XUN Xuejiao, LI Ying… - 临床肝胆病杂志, 2023 - lcgdbzz.org
Liver fibrosis is a key step in the progression of chronic liver diseases to liver cirrhosis and
even liver cancer. In recent years, a large number of studies have shown the necessity of …

[PDF][PDF] Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking …

RZ Jiang, YH Ling, XR Xian - Gastroenterol Hepatol Res, 2023 - tmrjournals.com
Objective: To study the mechanism of action of Xiayuxue Tang in treating hepatic fibrosis by
combining GEO data mining, network pharmacology, and molecular docking technology …