PACSIN proteins in vivo: Roles in development and physiology

V Dumont, S Lehtonen - Acta Physiologica, 2022 - Wiley Online Library
Protein kinase C and casein kinase substrate in neurons (PACSINs), or syndapins (synaptic
dynamin‐associated proteins), are a family of proteins involved in the regulation of cell …

Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction

P Goel, D Dickman - Cellular and Molecular Life Sciences, 2021 - Springer
Homeostatic signaling systems are fundamental forms of biological regulation that maintain
stable functionality in a changing environment. In the nervous system, synapses are crucial …

Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals

RB Walsh, EC Dresselhaus, AN Becalska… - Journal of Cell …, 2021 - rupress.org
Neuronal extracellular vesicles (EVs) play important roles in intercellular communication
and pathogenic protein propagation in neurological disease. However, it remains unclear …

An early endosome–derived retrograde trafficking pathway promotes secretory granule maturation

CIJ Ma, Y Yang, T Kim, CH Chen, G Polevoy… - Journal of Cell …, 2020 - rupress.org
Regulated secretion is a fundamental cellular process in which biologically active molecules
stored in long-lasting secretory granules (SGs) are secreted in response to external stimuli …

Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

K Kikuma, X Li, S Perry, Q Li, P Goel, C Chen… - Nature …, 2019 - nature.com
At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors
activates retrograde signaling that precisely increases presynaptic neurotransmitter release …

Disparate postsynaptic induction mechanisms ultimately converge to drive the retrograde enhancement of presynaptic efficacy

P Goel, X Li, D Dickman - Cell reports, 2017 - cell.com
Retrograde signaling systems are fundamental modes of communication synapses utilize to
dynamically and adaptively modulate activity. However, the inductive mechanisms that gate …

Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation

X Li, P Goel, C Chen, V Angajala, X Chen, DK Dickman - Elife, 2018 - elifesciences.org
Postsynaptic compartments can be specifically modulated during various forms of synaptic
plasticity, but it is unclear whether this precision is shared at presynaptic terminals …

The calcineurin regulator Sarah enables distinct forms of homeostatic plasticity at the Drosophila neuromuscular junction

NS Armstrong, CA Frank - Frontiers in synaptic neuroscience, 2023 - frontiersin.org
Introduction: The ability of synapses to maintain physiological levels of evoked
neurotransmission is essential for neuronal stability. A variety of perturbations can disrupt …

Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the Caenorhabditis elegans intestine

AM Gleason, KCQ Nguyen, DH Hall… - Molecular biology of the …, 2016 - Am Soc Cell Biol
Syndapin/pascin-family F-BAR domain proteins bind directly to membrane lipids and are
associated with actin dynamics at the plasma membrane. Previous reports also implicated …

Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth

GY Lee, TL Schwarz - Elife, 2016 - elifesciences.org
Filamin is a scaffolding protein that functions in many cells as an actin-crosslinker. FLN90,
an isoform of the Drosophila ortholog Filamin/cheerio that lacks the actin-binding domain, is …