Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Discovery of peptide domains with unique intermolecular interactions is essential for
engineering peptide-based materials. Rather than attempting a brute-force approach, we …

There is a challenging need for the development of new alternative nanostructures that can
allow the coupling and/or encapsulation of therapeutic/diagnostic molecules while reducing …

Neural tissue engineering holds great potential in addressing current challenges faced by
medical therapies employed for the functional recovery of the brain. In this context, self …

Repairing large tissue defects often represents a great challenge in clinics due to issues
regarding lack of donors, mismatched sizes, irregular shapes, and immune rejection. Three …

Peptide amphiphiles (PAs) have emerged as effective molecular building blocks for creating
self-assembling nanobiomaterials for multiple biomedical applications. Herein, we report a …

Tissue regeneration involves versatile types of cells. The accumulation and disorganized
behaviors of undesired cells impair the natural healing process, leading to uncontrolled …

The highly complex nature of spinal cord injuries (SCIs) requires design of novel
biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI …

Over the last decade, synthetically designed scaffolds are emerging as promising
biomaterials for tissue engineering applications. In this context, peptide hydrogels are …