Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Late-life depression (LLD) is one of the most common mental disorders among the older
adults. Population aging, social stress, and the COVID-19 pandemic have significantly …

Depression is a common psychological disease with high morbidity and mortality. Recently,
the involvement of synaptic plasticity in the pathogenesis of depression has shed light on the …

The human digestive tract is the cottage to trillions of live microorganisms, which regulate
health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial …

This systematic review evaluated the animal and human evidence for
pharmacomicrobiomics (PMx) interactions of antidepressant medications. Studies of gut …

Gut microbiome modulations allow new treatment strategies including the use of
psychobiotics for the treatment and prevention of mood disorders. Well designed clinical …

Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been
shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the …

The microbiota-gut-brain axis has been shown to influence human health and diseases,
including depression. The interactions between drugs and intestinal microbiota are complex …

Growing evidence supports the concept that bidirectional brain–gut microbiome interactions
play an important mechanistic role in aging, as well as in various neuropsychiatric …

The brain− gut− microbiome (BGM) axis affects host bioinformation. N-3 polyunsaturated
fatty acids (PUFAs) alleviate cognitive impairment and depression in older adults. This study …