Abstract Xenbase (www. xenbase. org) is an online resource for researchers utilizing
Xenopus laevis and Xenopus tropicalis, and for biomedical scientists seeking access to data …

Metal ions are critical to a wide range of biological processes. Among them, lithium (Li) has
been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet …

One of the most significant events during early embryonic development is the establishment
of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and …

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the
activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key …

Xenopus embryos provide a favorable material to dissect the sequential steps that lead to
dorsal–ventral (DV) and anterior–posterior (AP) cell differentiation. Here, we analyze the …

Abstract Retinol-binding protein 1 (RBP1) is involved in several physiological functions,
including the regulation of the metabolism and retinol transport. Studies have shown that it …

Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular
matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of …

As development proceeds, inductive cues are interpreted by competent tissues in a spatially
and temporally restricted manner. While key inductive signaling pathways within competent …

Deciphering the mechanisms of axis formation in amphioxus is a key step to understanding
the evolution of chordate body plan. The current view is that Nodal signaling is the only …

The Xenopus laevis embryo has been subjected to almost saturating screens for molecules
specifically expressed in dorsal Spemann organizer tissue. In this study, we performed high …