The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …

The E2F family of transcriptional regulators sits at the center of cell cycle gene expression
and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the …

Objective To observe the brain protective effect of Leonuri Herba Total Alkali (LHA) on
cerebral ischemia reperfusion injury in rats, so as to provide basis for clinical research …

Summary E2F1, E2F2, and E2F3A, the three activators of the E2F family of transcription
factors, are key regulators of the G1/S transition, promoting transcription of hundreds of …

The initiation of DNA replication involves cell cycle-dependent assembly and disassembly of
protein complexes, including the origin recognition complex (ORC) and CDC6 AAA+ …

OBJECTIVE An extracellular matrix such as collagen is an essential component of the tumor
microenvironment. Collagen alpha-2 (I) chain (COL1A2) is a chain of type I collagen whose …

The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and key
regulator of cell cycle progression. Since APC/C promotes the degradation of mitotic cyclins …

The cell cycle is principally controlled by Cyclin Dependent Kinases (CDKs), whose
oscillating activities are determined by binding to Cyclin coactivators. Cyclins exhibit …

Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and
degradation, and can be targeted for disease treatment when the abnormal expression of …

Abstract E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes
involved in S‐phase entry and progression. Previously, we demonstrated that these atypical …