Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

Allogeneic cell therapies, defined by genetically mismatched transplantation, have the
potential to become a cost-effective solution for cell-based cancer immunotherapy. However …

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make
them an attractive tool against graft-vs.-host disease (GVHD). However, despite promising …

We assessed the impact of the Janus Kinase (JAK) 1 inhibitor itacitinib on xenogeneic graft-
versus-host disease (xGVHD). XGVHD was induced by iv injection 20× 106 human …

Graft-versus-host disease (GVHD) is a T cell-mediated inflammatory disorder that arises
from allogeneic haematopoietic stem cell transplantation and is often fatal. The P2X7 …

Background Mucosal-associated invariant T (MAIT) cells are semi-invariant T cells that
recognize microbial antigens presented by the highly conserved MR1 molecule. MAIT cells …

Acute graft-versus-host disease (aGVHD) is a severe T cell-mediated immune response
after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the molecular …

Acute graft-versus-host disease (aGVHD) is a T cell–mediated immunological disorder and
the leading cause of nonrelapse mortality in patients who receive allogeneic hematopoietic …

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for
blood cancers and other haematological disorders. However, allo-HSCT leads to graft …

Endometriosis is a chronic inflammatory disease in which endometrial-like tissue grows
ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the …