With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

RNA molecules adopt specific three-dimensional structures critical to their function. Many
essential metabolic processes, including protein synthesis and RNA splicing, are carried out …

Group II introns are self-splicing, mobile genetic elements that have fundamentally
influenced the organization of terrestrial genomes. These large ribozymes remain important …

Group II introns are some of the largest ribozymes in nature, and they are a major source of
information about RNA assembly and tertiary structural organization. These introns are of …

Nearly two decades after Westhof and Michel first proposed that RNA tetraloops may interact
with distal helices, tetraloop–receptor interactions have been recognized as ubiquitous …

Transposable elements (TEs) make up a half of the human genome, but the extent of their
contribution to cryptic exon activation that results in genetic disease is unknown. Here, a …

RNA hairpins are the most commonly occurring secondary structural elements in RNAs and
serve as nucleation sites for RNA folding, RNA–RNA, and RNA–protein interactions. RNA …

Group II introns are large ribozymes that act as self-splicing and retrotransposable RNA
molecules. They are of great interest because of their potential evolutionary relationship to …

RNA crystals typically diffract to much lower resolutions than protein crystals. This low-
resolution diffraction results in unclear density maps, which cause considerable difficulties …

X-ray crystallography remains a powerful method to gain atomistic insights into the catalytic
and regulatory functions of RNA molecules. However, the technique requires the …