Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Class I histone deacetylases (HDACs) are closely associated with the development of a
diverse array of diseases, including cancer, neurodegenerative disorders, HIV, and …

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …

This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …

Background Nitrosatable drugs can be synthesized to N‐nitroso compounds in human
stomach. In a pregnant woman, N‐nitroso compounds can be translocated to the fetus …

Numerous metal-containing enzymes (metalloenzymes) have been considered as drug
targets related to diseases such as cancers, diabetes, anemia, AIDS, malaria, bacterial …

The pharmacoepigenetic apparatus is integrated by gene clusters of different categories,
including (i) pathogenic genes involved in disease pathogenesis,(ii) mechanistic genes …

Aliphatic aldehydes can be homologated to both one-carbon shorter and one-carbon longer
homologous carbonyl compounds through the 2–4 steps of reactions via the same …

Migraine is the third most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …